Aloysius T. Nchinda, K. Chibale, Pierre Redelinghuys
Sep 1, 2006
Citations
0
Influential Citations
35
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
With a view to developing a more C-domain-selective angiotensin I-converting enzyme (ACE)-inhibitor, a novel analogue of lisinopril has been synthesized which incorporates a bulky P(2)(') tryptophan functionality. This inhibitor demonstrated a significantly increased specificity for the C-domain as compared with lisinopril. Molecular docking revealed hydrophobic and hydrogen-bonding interactions with residues of the C-domain S(2)(') subsite.