Olivier Labeeuw, P. Phansavath, J. Genêt
Sep 13, 2004
Citations
0
Influential Citations
29
Citations
Journal
Tetrahedron Letters
Abstract
An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.