A. Sarhan, H. Soliman, Abdulrahman M. Saleh
Aug 10, 2021
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Journal
Egyptian Journal of Chemistry
Abstract
New 3-(3,4-dimethoxyphenyl)-1-(thiophene-2-yl)prop-2-en-1-one has been designed as a starting compound to synthesis a novel series of substituted pyrido[2,3-d]pyrimidine system incorporated to different Schiff's bases and enamine derivatives as potent antimicrobial compounds. Novel synthesized compounds were evaluated for their in-vitro antimicrobial potency against different gram-positive and gram-negative bacteria, where they reveal high effectuality at low concentration compared to Trimethoprim. Docking studies and structure-activity relationship declared that new pyrido [2,3-d] pyrimidines completely occupied the active pocket of Biotin Carboxylase of both bacterial types and fungal strains acting as selective Fatty Acid Synthesase type II inhibitors.