Ravi Kumar G. M. V. N. A. R., A. Thangamani
Jun 20, 2017
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Influential Citations
2
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Journal
Oriental journal of chemistry
Abstract
A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-aminoethanol or l-amino-2-propanol to afford the corresponding substituted 2-methyleneoxazolidines which are utilized in the synthesis of 6-aryl-2-amino-4-pyrimidinamine Derivatives. The molecular docking studies revealed that all the synthesized compounds best fit into the active site of HDAC2, anti-cancer protein.