G. Nawwar, B. Haggag, R. H. Swellam
1993
Citations
0
Influential Citations
11
Citations
Journal
Archiv der Pharmazie
Abstract
Several 1‐(hydroxy/substituted phenyl)propenones were tested as molluscicidal agents among which the 1‐(2‐hydroxy/substituted phenyl)‐3‐(2‐furyl)propenones 1a‐c show the most promising results. In an attempt to improve their activity, new dihydropyrazolo[1,5‐c][1,3]benzoxazines, their thio and their dehydrogenated derivatives were prepared. The pyrazolo[1,5‐c][1,3]benzoxazines 4a,b were hydrolyzed affording the 3‐(2‐furyl)‐5‐(2‐hydroxy/substituted phenyl) pyrazoles 8a,b. The hydroxyimino derivatives 10a‐c were synthesized together with their corresponding isoxazole derivatives 11a‐c. ‐ Molluscicidal assay indicated that the oximes 10b, c. the isoxazole 11b, the pyrazole 8b, and its N‐carbamoyl derivative 9b are most effective. They have in common the conjugated system shown in Fig. 1 which is presumably the active core.