N. V. Kaplina, A. Grinev, G. A. Bogdanova
Feb 1, 1987
Citations
0
Influential Citations
2
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
In continuation of our investigations on the synthesis of polyfunctional derivatives of thieno[2,3-d]pyrimidines [2, 3], we studied the brominationof 4-chloroand 4-methoxythieno[2,3-d]pyrimidines (Ia, b) and (Va, b) containing a methyl group at the 5or 6-position. It is known that bromination by molecular bromine of thieno[2,3-d]pyrimidines with no substituents at the 5and 6-positions, or containing a methyl group at the 5-position, is directed in both cases to the 6-position, and thus no bromination products have been noticed in the side-chain [5, 6].