Yu Yu
2013
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0
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Journal
Journal of Chongqing Medical University
Abstract
Objective:To design a method for synthesizing 1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride,which is an important intermediate for monoamine oxidase(MAO) inhibitors.Methods:1,2,3,4-tetrahydro-1-naphthylamine hydrochloride(11) was synthesized from benzene via acylation,reduction,cyclization,condensation,reduction,and salification by methods of Fridel Crafts acylation,Wolf-kishner-HUANG Minglong reduction and Harwoth cyclization.Results:Overall yield for synthesizing 1,2,3,4-tetrahydro-1-naphthylamine hydrochloride(11) was 43.6%.Conclusions:Method for synthesizing 1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride is establish.Optimized synthetic route has advantages in industrial production for its cheap and readily available raw materials,easy in operation,high yield and high quality of products.