Y. Zhuo
2006
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Journal
Chinese Journal of New Drugs
Abstract
Objective:To synthesize antiarrythmic drug moracizine hydrochloride.Methods: Starting from 3-bromonitrobenzene and acetanilide,the intermediate 3-nitrodiphenylamine was obtained via alkylation and hydrolysis.Subsequently,the target compound was synthesized via several chemical re- actions including reduction,acylation,cyclization,alkylation and saltization.Results:The total yield of moracizine hydrochloride was 35.8%,and the structure was verified by ~1H-NMR and MS.Conclusion:An easily manipulated synthetic procedure of moracizine hydrochloride was achieved for further pilot manufacture.