Y. Guan
2014
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Journal
Journal of Dalian University
Abstract
Through condensation reaction of moroxydine chloride and dicyandiamide, Moroxydine Hydrochloride was synthesized under the condition of Ionic liquid as reaction solvent. Factors affecting on the yield was studied,such as the amount of ionic liquid, reaction time, molar ratio, reaction temperature. Isolation and purification of Moroxydine Hydrochloride and ionic liquids was studied. The results show that: in the ionic liquid as a reaction solvent, the synthesis method of Moroxydine Hydrochloride is simple and easy separation. Through the influence of factors investigated, the optimal synthesis condition was found. The optimal conditions for the material ratio is 1:1.1; reaction time is 3 hours; condensation reaction temperature was 135 ℃.