Shunya Takahashi, Akemi Kubota, T. Nakata
Nov 25, 2002
Citations
0
Influential Citations
31
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An antitumor acetogenin, muconin, was synthesized through a coupling reaction of a THF–THP segment and a terminal butenolide. The key reactions include 6- exo cyclization of an epoxy tetraol, regioselective cyclization of hydroxy tosylate, and stereoselective reduction of an acyclic ketone adjacent to the 2,6- cis THP ring with Zn(BH 4 ) 2 .