Honghao Chen, Lu Ouyang, Jidan Liu
Jun 13, 2019
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0
Influential Citations
19
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient [2+2+2] benzannulation of phthalic acids/anhydrides with two alkynes was developed for synthesis of multisubstituted 1-naphthoic acids via Ru-catalyzed C-H activation. The reaction preceded well using atmospheric oxygen as the sole oxidant with high atom/step economies. Facilitated by the free carboxyl group, the products can be easily converted to diverse polycyclic molecules.