Akiko Ueno, Takafumi Kitawaki, N. Chida
Apr 11, 2008
Citations
1
Influential Citations
43
Citations
Journal
Organic letters
Abstract
The total synthesis of (+/-)-murrayazoline (1) is described. The characteristic hexa-heterocyclic structure of 1 was constructed by a combination of the intramolecular Friedel-Crafts-type Michael addition and Pd-catalyzed C-O coupling reactions. The N-substituted carbazole component was synthesized in one pot by the double N-arylation of a sterically hindered amine with a dibromobiphenyl derivative.