M. Bosiak, Marek P. Krzemiński, P. Jaisankar
May 1, 2008
Citations
1
Influential Citations
25
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The asymmetric synthesis of two 5-lipoxygenase inhibitors ( R )- N -1-(benzofuran-2-yl)ethyl- N -hydroxyurea, 99% ee, and ( R )- N -1-(benzo[ b ]thiophen-2-yl)ethyl- N -hydroxyurea, 95% ee, is described. The enantioselective reduction of 1-(benzofuran-2-yl)ethanone oxime O -benzyl ether and 1-(benzo[ b ]thiophen-2-yl)ethanone oxime O -benzyl ether with borane oxazaborolidine, generated from (1 R ,2 S ,3 R ,4 S )-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, was used for the formation of the stereogenic centres.