H. Mereyala, Kalyani Sambaru
May 10, 2005
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Journal
ChemInform
Abstract
Nitration, benzylation followed by bromination of 4- hydroxyacetophenone is described to obtain nitrobenzyloxyphenacyl bromide derivative 3. Sodiumborohydride reduction of 3 gives rise to the diol 6. Reaction of 6 with Ph 3 P/I 2 /imidazole yields styrene derivative 7. Compound 7 on selective reduction of the nitro group followed by N-formylation and epoxidation affords the key intermediate N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide 4.