A. Gibbs, H. Morimoto, H. VanBrocklin
Apr 1, 2002
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0
Influential Citations
4
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The preparation of the title compound, [3H3]CNS-5161, was accomplished in three steps starting with the production of [3H3]iodomethane (CT3I). The intermediate N-[3H3]methyl-3-(thiomethylphenyl)cyanamide was prepared in 77% yield by the addition of CT3I to 3-(thiomethylphenyl)cyanamide, previously treated with sodium hydride. Reaction of this tritiated intermediate with 2-chloro-5-thiomethylaniline hydrochloride formed the guanidine compound [3H3]CNS-5161. Purification by HPLC gave the desired labeled product in an overall yield of 9% with >96% radiochemical purity and a final specific activity of 66 Ci mmol−1. Copyright © 2002 John Wiley & Sons, Ltd.