Yang Jun
2004
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Journal
Fine Chemical Intermediates
Abstract
The synthesis of N-(2-hydroxyethyl)phthalimide via Gabriel synthesis method was reported. Potassium phthalimide reacted with 2-chloroethanol under 90?℃ or 12?h in DMF solvent, and the isolation yield was about 86%. The influences of reaction temperature,time,ratio of reactants,and solvent on the yields were discussed.The manipulation of this method was simple and it was easy to work up,which had its advantage on preparation of N-(2-hydroxyethyl)phthalimide on labortory scale.