V. Dorokhov, S. Baranin, A. Dib
Sep 1, 1990
Citations
0
Influential Citations
5
Citations
Journal
Bulletin of the Academy of Sciences of the USSR, Division of chemical science
Abstract
The reaction of 2-aminopyridine and 2-aminopicolines with ethyl cyanoacetate under high pressures results in the formation of 4-amino-4H-pyrido[1,2-a]pyrimidin-2-ones. Depending on the structure of the initial pyridine base, heating of a mixture of the above reagents under low vacuum gives either the same products or their isomeric N-(2-pyridyl)cyanoacetamidēs. The mutual transformations of the synthesized isomers were studied; it was found that cyanoacetamides are readily cyclized by the action of an alcoholic solution of HCl into pyrido[1,2-a]pyrimidin-2-ones, while the latter, during sublimation or heating in DMSO, undergo opening of the pyrimidine ring.