B. Raju, P. Neelakantan, U. Bhalerao
2007
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Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
Reaction of 4-benzyloxy-3,5-dimethyl benzyl bromide 4 and N-tosyl-3,4-dimethoxy benzyl amine 5 gives the N-(4'-benzyloxy-3',5'-dimethylbenzyl)-N-tosyl-3,4-dimethoxybenzyl amine 6. The obtained product on debenzylation affords N-(3',5'-dimethyl-4'-hydroxybenzyl)-N-tosyl-3,4-dimethoxybenzyl amine 7 in 94% yield, which is key intermediate in the synthesis of isoindolines.