Gong Fenga
2007
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0
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Journal
Journal of Huaihai Institute of Technology
Abstract
N-[3-((3-(Dimethylamino)-1-oxo-2-propenyl)phenyl]-N-ethyl acetamide was synthesized from m-nitro acetophenone by reduction,acetylation,ethylation and condensation with an overall yield of 77%.Improvements for the technical methods of reduction,acetylation and ethylation were also studied.N-(3-acetylphenyl) acetamide was obtained through one pot procedure of reduction and acetylation with the yield of 85%.In ethylation reaction,sodium hydride was replaced by potassium hydroxide,acetone as solvent and bromoethane as ethylating reagent,which is convenient to operate and the cost was decreased.The yield of this step was 98.5%.The purity of title compound was over 99% by HPLC.This procedure was simple,safe,mild and suitable to scale-up production.