T. Bach, H. Brummerhop
Apr 1, 1999
Citations
0
Influential Citations
3
Citations
Journal
Journal Fur Praktische Chemie-chemiker-zeitung
Abstract
The title compounds 1 were prepared from the corresponding N-acceptor substituted 2-methoxypyrrolidines 3by elimination with trimethylsilyl trifluoromethanesulfonate (TMSOTf) and N,N-di-iso-propyl ethyl amine (6 examples, 57–84% yield). The enantiomerically pure N-methoxy-carbonyl protected elimination substrates 3aa and 3ab were synthesized from the L-pyroglutamic acid derived pyrrolidinones 6a and 6b in three steps (80–83% yield overall).