Qing-Zhong Zheng, Kui Cheng, Xiao-min Zhang
Jul 1, 2010
Citations
1
Influential Citations
34
Citations
Quality indicators
Journal
European journal of medicinal chemistry
Abstract
A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi.