Aleš Machara, D. Cox, T. Hudlický
Oct 8, 2012
Citations
1
Influential Citations
27
Citations
Journal
Advanced Synthesis & Catalysis
Abstract
Oxymorphone was converted to naltrexone in three steps by palladium-catalyzed oxidative N-demethylation and intramolecular acyl transfer from C-14 hydroxy to N-17. Vitride™ reduction of N-acylamide to N-alkylamine proceeded with concomitant reductive deprotection of C-6 and O-3 functionalities.