S. Duan, Dilip K. Sinha-Mahapatra, J. Herndon
Mar 20, 2008
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0
Influential Citations
47
Citations
Journal
Organic letters
Abstract
The synthesis of naphthalene derivatives through three-component coupling of 2-alkynylbenzaldehyde hydrazones with carbene complexes and electron-deficient alkynes has been examined. The reaction involves formation of an isoindole derivative, followed by intramolecular Diels-Alder reaction, followed by nitrene extrusion. The reaction was highly regioselective using unsymmetrical alkynes.