V. Osyanin, D. Osipov, Y. Klimochkin
Apr 6, 2012
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Influential Citations
3
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Journal
Chemistry of Heterocyclic Compounds
Abstract
Condensed 1,2,4-triazoles find use in human and veterinary medicine as tranquilizers [1], fungicides [2], antihistamine [3], and antihypertensive [4] preparations. In continuing our studies of the synthetic potential of naphthalene series o-quinone methides for the preparation of condensed azolo-1,3-oxazines [5] we have carried out a one-stage synthesis of the naphtho[1,2-e][1,2,4]triazolo[5,1-b][1,3]oxazines 2a,b from 3,5-dibromo-1,2,4triazole and the Mannich base 1b or its quaternized analog 1a in the presence of K2CO3. We have also found that derivative 1a in refluxing acetonitrile in the absence of the potassium carbonate selectively formed 1-[(3,5dibromo-1H-1,2,4-triazol-1-yl)methyl]-2-naphthol (3).