Cécile Croix, S. Massip, M. Viaud-Massuard
May 29, 2018
Citations
0
Influential Citations
4
Citations
Journal
Chemical communications
Abstract
The reaction of 3-substituted 1H-pyrrolo[2,3-b]pyridin-2(3H)-one derivatives with sodium azide or azidotrimethylsilane under microwave irradiation provided 3- and 4-amino-naphthyridin-2(1H)-one derivatives through cycloaddition-ring expansion. The insertion of the azide into the α,β unsaturated carbonyl of 3-substituted pyrrolo[2,3-b]pyridin-2(3H)-one derivatives proceeded via an unusual rearrangement. This methodology provided 39 ring expansion examples in moderate to good yields.