Tan Shi-gui
2004
Citations
0
Influential Citations
0
Citations
Journal
Fine Chemical Intermediates
Abstract
The preparation of a new antidiabetic drug cis-isomer nateglinide was first time described. In experiments ,4-isopropylbenzoate was dissolved in acetic acid ,which washydrogenated by catalyzers PtO_ 2 and the results were the mixture of 4-isopropylcyclohexane carboxylic acid. By treatment above mixture with thiourea and N-Hydroxysuccinimide, Cis-4-isopropylcyclohexane amboryl formate was obtained and them reacted with D-Phenylalanine methyl esterhydrochloride andhydrolyzed on basic. Finally , cis-nateglinide was obtained. The total yields is 7.63% according to the initial material 4-isopropylbenzoate and the purity is 98.8%.