M. Sibi, Sagar S. Thorat
Oct 1, 2023
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Arkivoc
Abstract
Tetralone and its derivatives are unique structural motifs found in a wide range of natural products and serve as key scaffolds for the development of new drugs that target various biological end points. The tetralones have received a lot of interest because of their chemical features and their potential as lead molecules in the pharmaceutical sector. The goal of this review is to present the total synthesis of natural products bearing the 1-tetralone subunit, as well as to highlight key transformations for the synthesis of 1-tetralone. It summarizes the total syntheses of several natural products containing the tetralone subunit, such as 10-norparvulenone, catalponol, aristelegone-A, perenniporide A, and actinoranone