Jianqing Zhang, Yongli Duan, Hehua Xiong
Jul 9, 2019
Citations
0
Influential Citations
1
Citations
Journal
IOP Conference Series: Earth and Environmental Science
Abstract
1-(N, N-dimethyl) amine-2-(o-chlorobenzoyl)-methyl acrylate is an important intermediate for the many biologically active anticancer drugs. In this research, a rapid and efficient synthesis of compounds 8 was established. Compound 8 consisting of o-chloroacetophenone and dimethyl carbonate was synthesized by two steps including nucleophilic substitution and carbanion reaction. The synthesis method was optimized, and structure was confirmed by 1H NMR and MS spectrum. The synthesis method is optimized. The total yield of the two steps is 63.69%.