Ding Cheng-ron
2013
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
The synthesis of 3-(N-ethyl-N-methoxycarbonylmethyl) amino acetanilide via two-step reactions was reported,with 3-aminoacetanilide as starting material.The designed product was yielded by the ethylated compound(from 3-aminoacetanilide reacting with acetaldehyde) reacting with methyl chloroacetate.The optimized reaction conditions were as follows: in the first step,the yield of 3-(Nethyl) amino acetanilide was 90.7% and its purity was up to 97.5%,when the molar ratio of acetaldehyde to 3-aminoacetanilide was 1.0∶1.2 and when 5% Pd/C was used as catalyst under 3.5 MPa of hydrogen atmosphere at 70 ℃.In the second step,the designed product was obtained in 94.6% yield and 96.8% purity with 0.6 equiv.of sodium carbonate as deacid reagent under 70 ℃.