Xia Kun, W. Xin
2006
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Employing DIC as carboxyl activating agent,N-Fmoc leucine reacted smoothly with Meldrum's acid to produce 1,3-dioxane-4,6-dione derivative,which was converted directly to tertramic acid by reflux with ethyl acetate without further purification.The resulting tetramic acid was reduced by NaBH_4 to afford 4-hydroxy-pyrrolidine-2-one derivative,which was further hydrolyzed in acid media to yield the desired N-Fmoc Statine.The chirality of the synthesized N-Fmoc Statine was also well studied.