John C. Stowell, Rachel I. Huot, Lainie Van Voast
Apr 14, 1995
Citations
2
Influential Citations
50
Citations
Journal
Journal of medicinal chemistry
Abstract
We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at 10(-5) M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.