A. Humphrey, S. Parsons, Mark E. B. Smith
Jun 8, 2000
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
N-Hydroxypyrrolidine 5 has been prepared in nine steps starting from 3-O-benzylglyceraldehyde 13. The synthetic route employs Escherichia coli transketolase mediated C–C bond synthesis to establish the absolute stereochemistry and a subsequent ring contraction of a 1,2-oxazine 17 to provide the N-hydroxypyrrolidine nucleus.