E. Brambilla, E. Disalle, G. Briatico
Jul 1, 1989
Citations
0
Influential Citations
38
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract The synthesis and the nidation inhibitory activity (indirect evidence of prolactin activity) of a new class of ergolinyl-acylureas is described. Some structure—activity relationship considerations are also reported. N -[3-(Dimethyl-amino)propyl]- N -[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8β-carboxamide (laboratory code FCE 21336; international non-proprietary name cabergoline) was the most interesting compound of the series and is now under extensive clinical evaluation in treatment of hyperprolactinemic disorders.