M. Jachak, M. Mittelbach, H. Junek
1993
Citations
0
Influential Citations
8
Citations
Journal
Heterocycles
Abstract
The reactivity of 3-dimethylamino-2-formylpropenenitrile (1) with various amino compounds is studied. Thus, condensation of 1 with anilines gives the corresponding azomethines (2a-c). Reaction of 1 with thiourea and guanidine resp., leads to 5-formylthiocytosine (3) and 2-amino-5-cyanopyrimidine (4). The 2-formyl-3-ureidopropenenitriles (5a-i) can be obtained by reaction of 1 with urea and substituted ureas. 5a-i can easily be cyclized to 3-substituted 5-formylcytosines (6a-e). Condensation of 6 with aniline, benzylamine and phenylhydrazine leads to the azomethines (7a-i). Pyrido [2,3-d] pyrimidine-6-carbonitriles (8a, 8b, 8d and 8e) are obtained by reaction of 6 with malononitrile