He Li-li
2007
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Journal
Fine chemicals
Abstract
2-Hydroxy-3-naphthoyl chloride was synthesized by 2-hydroxy-3-naphthoic acid and thionyl chloride,and then reacted with methyl substituted phenylureas to prepare N-(methyl substituted phenyl)-N′-(2-hydroxy-3-naphthoyl)urea.Thus,the optimal conditions for preparing N-(3-methylphenyl)-N′-(2-hydroxy-3-naphthoyl)urea were:using benzene as solvent and triethylamine as acid binding agent,n(3-methylphenylurea)∶n(2-hydroxy-3-naphthoylchloride)∶n(benzene)=1∶3∶33,reacting at reflux temperature and reaction time 4 h.The purity and yield of the compound obtained was 97.40% and 71.5% respectively.Similarily,N-(2-methylphenyl)-N′-(2-hydroxy-3-naphthoyl)urea,N-(4-methylphenyl)-N′-(2-hydroxy-3-naphthoyl)urea and N-(3,5-dimethylphenyl)-N′-(2-hydroxy-3-naphthoyl)urea were also synthesized.Their purities were 95.72%,97.69% and 99.44%,and their yields were 47.1%,71.5% and 59.7% respectively.Structures of the products were determined by UV,IR and MS.