H. Muramatsu, H. Mihara, Ryo Kakutani
Sep 20, 2004
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract An enzymatic system for the synthesis of N-methyl- l -phenylalanine from phenylpyruvic acid and methylamine with a novel enzyme, N-methyl- l -amino acid dehydrogenase from Pseudomonas putida ATCC12633, using NADP+ and glucose dehydrogenase from Bacillus subtilis as a co-factor-recycling system is described. Analysis of the product on a laboratory preparative scale process revealed N-methyl- l -phenylalanine in 98% yield and over 99% ee. N-Methyl- l -phenylalanine can be used as chiral building blocks for the synthesis of several products with pharmacological activity.