Wang Ping-bao
2008
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Journal
Fine Chemical Intermediates
Abstract
N,N′-di-Boc-1H-pyrazole-1-carboxamidine was synthesized from 1H-pyrazole-1-carboxamidine hydrochloride(PJ). PJ was treated with di-tert-butyl dicarbonate in the presence of K2CO3 to give N-Boc-1H-pyrazole-1-carboxamidine(PB),then PB reacted with di-tert-butyl dicarbonate in the presence of 4-dimethylaminopyridine to give N,N,N′-tri-Boc-1H-pyrazole-1-carboxamidine(PT),PT reacted with Mg(ClO4)·6H2O to give N,N'-di-Boc-1H-pyrazole-1-carboxamidine(PM). The overall yield and the purity product was 65.9% and 99.0%,respectively. The structure of the product was identified by m.p.,1H NMR and MS.