A. Plenevaux, C. Lemaire, A. J. Palmer
Aug 1, 1992
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Influential Citations
25
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Journal
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
Abstract
Abstract The synthesis of no-carrier-added 3-[18F]fluoroanisole, 2-[18F]fluoroanisole, [18F]fluorobenzene and 4-[18F]fluoroveratrole are reported. The strategy consists of amino-polyether supported nucleophilic substitution with [18F]F− on activated nitro aromatic aldehyde precursors followed by decarbonylation using Tris(triphenylphosphine) rhodium (I) chloride. The experimental parameters for this reaction have been studied and optimized with 2-[18F]fluoro-4-methoxybenzaldehyde and then successfully applied to four other 18F-fluorinated aromatic aldehydes. The decarbonylation yields obtained were 84 ± 5% (corrected for decay) within 15 min at 150°C in 1,4-dioxan.