L. Martin, S. Scott, L. Setescak
Nov 1, 1987
Citations
0
Influential Citations
15
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
1,2,3,4-Tetrahydrobenzo[c]-1,5-naphthyridine (5a) was prepared by a novel synthetic route involving the rearrangement of (±)-(Z)-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10(2H,5H)-dione oxime to afford 1,4-dihydrobenzo[c]-1,5-naphthyridin-2(3H)-one, which was reduced to 5a. The cholinomimetic activity observed with 5a prompted the synthesis and biological evaluation of additional analogues.