V. Alagarsamy, D. Shankar, V. Solomon
Feb 22, 2007
Citations
0
Influential Citations
16
Citations
Journal
Arkivoc
Abstract
A variety of novel 2-mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo(4,5) thieno(2,3-d)pyrimidin-4-ones were synthesized by reacting 3-Amino-2-mercapto-5,6,7,8- tetrahydro-3H-benzo(4,5)thieno(2,3-d)pyrimidin-4-one with different aldehydes and ketones; the starting material 3-amino-2-mercapto-5,6,7,8-tetrahydro-3H-benzo(4,5)thieno(2,3-d)pyrimidin- 4-one was synthesized from 2-amino-3-carbethoxy-4,5,6,7-tetrahydrobenzo thiophene by a novel innovative route. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds AS1, AS2 and AS3 showed more potent analgesic activity. The compound AS3 showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly the test compounds showed only mild ulcerogenic potential when compared to aspirin.