Yang Qi-don
2015
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A key intermediate,4-[4-( 4-methoxyphenyl) piperazine-1-yl]aniline( 4),was prepared by a four-step reaction of bromination,cyclization,N-alkylation and reduction,using diethanolamine as material. Eleven novel 1-( 4-aminophenyl)-4-( 4-methoxyphenyl) piperazine derivatives were synthesized by acylation reaction of 4 with acyl chloride. The structures were characterized by1 H NMR,FT-IR,ESI-MS and elemental analysis.