M. Vosooghi, Soghra Farzipour, Mina Saeedi
Mar 21, 2015
Citations
0
Influential Citations
16
Citations
Journal
Journal of the Iranian Chemical Society
Abstract
A simple and practical method is described for the synthesis of novel 5-arylidene derivatives of barbituric and thiobarbituric acid. 2-Formylbenzoic acids reacted easily with (thio)barbituric acids in the presence of p-toluenesulfonic acid (p-TsOH) in MeOH/EtOH to obtain the title compound in good yields. Then, their urease inhibitory activity were evaluated in vitro and compared with hydroxyurea as the reference drug.Graphical Abstract