O. O. Alekseeva, A. Mahadevan, J. Wiley
Mar 21, 2005
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A facile seven-step sequence was developed from 4′-bromopropiophenone, utilizing a Suzuki-type coupling with an alkene, to give several novel 5-substituted pyrazole derivatives in overall yields of 11–31%. They are potent CB1 antagonists and have binding affinities similar to SR 141716A. Like SR 141716A, they may prove to be clinically useful for the treatment of obesity.