H. Bi
2015
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A intermediate,4-bromo-2-( bromomethyl)-1-[( 4-chlorobenzyl) oxy]benzene( 3),was prepared by elimination reaction,reduction reaction and bromization using 1-chloro-4-( chloromethyl)benzene and 5-bromo-2-hydroxybenzaldehyde as the starting materials. 4-Chloro-N-ethyl-N-( piperidin-4-yl) benzamide( 7) was prepared by a four-step reaction from piperidin-4-one. A novel non-peptide CCR5 antagonist, N-【1-{ 5-bromo-2-[( 4-chlorobenzyl) oxy]benzyl } piperidin-4-yl 】-N-ethylbenzamide,was synthesized by elimination reaction of 3 with 7. The structure was characterized by1 H NMR,13 C NMR and ESI-MS.