V. Guguloth
2021
Citations
0
Influential Citations
0
Citations
Journal
Journal name not available for this finding
Abstract
ABSTRACT A series of novel 4-(2-hydroxy-3-(4-phenylpiperazin-1-yl) propyl)-2H-benzo[b][1,4]oxazin-3(4H)-one derivative have been synthesized in good yields and the crucial intermediate 4-(oxiran-2-methyl)-2H-benzo[b][1,4]oxazin3(4H)-one was obtained by the reaction of 4-allyl-2H-benzo[b][1,4]oxazin-3(4H)-one with K2OSO4, K2[Fe(CN)6], K2CO3, tBuOH in water to cis-diol compound of 4-(2,3-dihydroxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one, followed by protection and deprotection of primary alcohol of 2-hydroxy-3-(3-oxo-2,3-dihydro-4Hbenzo[b][1,4]oxazin-4-yl)propyl-4-methyl benzenesulfonate and were characterized by using 1H NMR, IR and Mass spectroscopic methods and they were good agreement with the proposed structures.