X. Hou, Binfeng Li, L. Dai
Jun 18, 1999
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Influential Citations
17
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The chiral building block ( S )- N -benzyl- N -isopropyl-2,3-epoxypropylamine is obtained by means of chlorohydroxylation of allylamine, followed by Jacobsen's hydrolytic kinetic resolution with water. A concise, divergent five-step synthesis of three β-adrenergic blocking agents in high enantiomeric excess using ( S )- N -benzyl- N -isopropyl-2,3-epoxypropylamine as the key intermediate is described.