V. L. Gein, N. V. Nosova, A. Yankin
Jun 13, 2019
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple, inexpensive and stereoselective synthesis of novel functionalized cyclohexanone derivatives via the reaction of acetoacetamide with aromatic aldehydes in ethanol at room temperature is described. Additionally, the presence of substituents such as NO 2 and Cl in the ortho -position of the aldehyde aromatic ring resulted in the formation of novel piperidines. The use of Lewis acids such as iron(III) chloride and bismuth(III) nitrate as catalysts led to autocondensation of acetoacetamide and the formation of 2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide.