A. Grigor’ev, S. Karpov, Ya. S. Kayukov
Nov 4, 2015
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
An efficient one-step synthesis of novel 4-acyl-2-amino-3,5-dicarbonitrile-6-sulfanylpyridines has been developed via the reaction of 2-acyl-1,1,3,3-tetracyanopropenides with thiols in DMSO containing dimsyl sodium. 2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines are the subject of considerable interest due to their wide range of pharmaceutical, biological, and medicinal applications and currently serve as a ‘privileged scaffold’ due to their potential therapeutic applications.