Wang Xiao-long
2011
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
(Z)-4-[2-(1-chloro-2-ethoxy-2-oxoethylidene)hydrazinyl]benzoic acid(1) was prepared from p-aminobenzoic acid by diazotization,then reacted with ethyl 2-chloro-acetoacetate.A novel Hsp90 inhibotor,ethyl 1-{4-[(4-hydroxycyclohexyl)carbamoyl]phenyl}-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate(3),was synthesized by cyclization between 1 and 5,5-dimethyl-cyclohexane-1,3-dione,then amidation with p-hydroxyl-cyclohexylamine.The structure was characterized by 1H NMR.The result from fluorescence polarization showed that 3 exhibited good inhibition against Hsp90α.