J. Liu
2013
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
6-[(Trifluoromethyl) phenyl]-4-hydroxyl-2-aminopyrimidine(2) was prepared by condensation of ethyl acetate with methyl 3-oxo-3-[4-(trifluoromethyl) phenyl]propanoate in THF using NaH as the catalyst. Three novel imidazo[1,2-a]pyrimidine compounds were synthesized by cyclization of 2 with guanidine,and then cyclization with 2-bromo-1-(4-chlorophenyl) ethanone,chlorination with phosphoryl trichloride and aminization with amines. The structures were characterized by 1H NMR and IR.